Dr. Sholler is board certified in pediatric hematology-oncology (cancer and blood disorders) and is known around the world for her groundbreaking research. She specializes in pediatric solid tumors with a focus on neuroblastomas, diffuse intrinsic pontine gliomas (DIPG), embryonal tumors with mutilayered rosettes (ETMR) and medulloblastomas. 

She is the director of the Isabella Santos Foundation Rare and Solid Tumor Program at Levine Children’s and the professor of pediatrics and principal investigator of the Sholler Pediatric Oncology Research Laboratory at Levine Children’s Hospital. She is also the chair of the Beat Childhood Cancer Consortium. 

She has been honored with the WGVU Engage Award for Person of the Year in 2015 and the Barton Kamen Metronomics Global Health Initiative Award in 2016. 

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The research she conducts at the Sholler Pediatric Oncology Research Laboratory focuses on 3 main areas. First is the targeting of neuroblastoma cancer stem cells to prevent relapse focused on a drug called DFMO. The second is in precision medicine through testing of novel agents for a panel of cancers including neuroblastomas, brain tumors and sarcomas to develop new clinical trials. The third is in the genomic understanding of patient tumors and generation of individual patient tumor models.